Article Details


Cannabinoids and Neuro-Inflammation: Regulation of Brain Immune Response

[ Vol. 10 , Issue. 2 ]

Author(s):

Roberta Ranieri, Chiara Laezza, Maurizio Bifulco, Daniela Marasco and Anna M. Malfitano   Pages 178 - 203 ( 26 )

Abstract:


Background: Cannabinoid receptors are involved in the neuro-pathogenic mechanisms of inflammatory conditions of the central nervous system and their expression can be modulated during diseases.

Methods: In this manuscript we highlight the function of cannabinoid receptors, their signalling and expression at peripheral and central levels in order to understand their implication in neuro-inflammation and review the effects of cannabinoids in neuro-inflammatory disorders.

Results: Brain inflammatory processes are characterized by infiltration of numerous types of cells: both peripheral and brain resident immune cells and other neuronal cells. The disruption of the blood brain barrier favours cell infiltration in the central nervous system with consequent neuronal damage, a common event in many neuro-inflammatory diseases. Cannabinoids affect brain adaptive and immune response, regulate inflammatory mediators and can exert a role in blood brain barrier damage prevention.

Conclusion: Various patents describe the beneficial properties of cannabinoids in numerous neurodegenerative diseases with inflammatory components and overall effects support the therapeutic application of cannabinoids.

Keywords:

Cannabinoids, cannabinoid receptors, neuro-inflammation, immune response, blood brain barrier, brain, neurode generative diseases.

Affiliation:

Department of Medicine and Surgery, University of Salerno, Via Salvatore Allende, Baronissi, 84081 Salerno, Italy and Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 84084 Fisciano (Salerno)- Italy.



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